https://www.live-feeds.com/feed/the-blood-metabolome-of-brain-health-in-midlife-and-influences-of-genes-microbiome-and-exposomeContinuously updated, source-cited coverage. https://www.live-feeds.com/feed/the-blood-metabolome-of-brain-health-in-midlife-and-influences-of-genes-microbiome-and-exposomehttps://www.live-feeds.com/feed/the-blood-metabolome-of-brain-health-in-midlife-and-influences-of-genes-microbiome-and-exposome#u21716Thu, 02 Jul 2026 18:42:09 +0000Researchers analyzed 991 blood metabolites in 1,082 dementia-free middle-aged participants from the Rotterdam Study. The study found that fourteen metabolites have replicated associations with cognition, with ergothioneine showing the largest effect. These metabolic signatures mirror those found in incident Alzheimer's disease.What's confirmed:Fourteen metabolites showed replicated associations with cognition, with ergothioneine exhibiting the largest effect.The metabolite signature of cognition mirrored that of incident Alzheimer's disease.Lifestyle, clinical variables and medicatio